Genotypic Distribution and Antimicrobial Susceptibilities of Carbapenemase-Producing Enterobacteriaceae Isolated in Tertiary Care Hospital in South India

Antimicrobial resistance has emerged as a major danger to contemporary medicine around the world. Carbapenems are highest class of B-lactam drugs which considered most effective and safest antibiotics available. Increasing spread carbapenemases been noted across world restricts treatment options. The aim this study was determine incidence carbapenem resistant genotypic pathways in tertiary care hospital. 130 clinical strains Enterobacteriaceae were subjected Kirby-Bauer disk diffusion tests methods (PCR) for identification genes NDM, VIM, OXA-48. Carbapenem detected 30% isolates by phenotypic methods. These 37 on being subject PCR showed OXA-48 followed VIM NDM frequently isolated genotypes. All had multiple encoding resistance. Carbapenemases is rise associated with multi drug pattern. To minimize initiate early appropriate therapy, detection essential. Molecular remain gold standard detection.